triadafight.blogg.se - Mal de diogenes

Jerónimo-Santos A, Fonseca-Gomes J, Guimarães DA, Tanqueiro SR, Ramalho RM, Ribeiro JA, Sebastião AM, Diógenes MJ (2015) Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced toxicity through a mechanism independent on adenosine 2A receptor activation. (2015) Presymptomatic and symptomatic ALS SOD1(G93A) mice differ in adenosine A1 and A 2A receptor-mediated tonic modulation of neuromuscular transmission. Ribeiro FF, RNeves-Tomé R, Assaife-Lopes N, Santos TE, Silva RFM, Brites D, Ribeiro JA, Sousa MM, Sebastião AM (2015) Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons. Purine nucleosides in neuroregeneration and neuroprotection, Neuropharmacology 104:226-242. Ribeiro FF, Xapelli S, Miranda-Lourenço C, Tanqueiro SR, Fonseca-Gomes J, Diógenes MJ, Ribeiro JA, Sebastião AM (2016). Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation. Mouro FM, Batalha VL, Ferreira DG, Coelho JE, Baqi Y, Müller CE, Lopes LV, Ribeiro JA, Sebastião AM (2017). Ex vivo model of epilepsy in organotypic slices-a new tool for drug screening. Magalhães DM, Pereira N, Rombo DM, Beltrão-Cavacas C, Sebastião AM, Valente CA (2018). Funding Agency: Fundação para a Ciência e a Tecnologia. Funding Agency: Fundação para a Ciência e a Tecnologia.Ģ018/2021 Controlo mecanistico e optogenético da astroglia para reparação neuronal. Funding Agency: Fundação para a Ciência e a Tecnologia.Ģ018/2021 Titanic- CYP46A1 as new Therapeutic Target in Niemann-Pick Type-C disease. Funding Agency: Fundação para a Ciência e a Tecnologia.Ģ018/2021 Regulação da homeostase e polarização pró-inflamatória da microglia Rac1.

Coordinator: Coordinator: Ana M Sebastião.

Funding Agency: Fundação para a Ciência e a Tecnologia.Ģ018/2021 Na procura do mecanismo de ação de um novo e seletivo fármaco antiepiléptico. Funding Agency: Fundação para a Ciência e a Tecnologia.Ģ018/2021 Astrossomas: Astrócitos Artificiais como reguladores da comunicação neuronal. Funding Agency: European Commission.Ģ018/2021 Restabelecimento dos níveis de Adenosina: nova abordagem para o tratamento da Sindrome de Rett. Ongoing Research Projects 2020/2023 Twinning - EpiEpiNet - Epileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies.

Control of post-natal neurogenesis and oligodendrogenesis. The group aims to understand how post-natal formation of new neurons and oligodendrocytes is regulated and its implications for the control of neuronal diseases as multiple sclerosis.

Neurobiology of inflammation - interplay with epilepsy. This group aims to understand the relationship between inflammation and epilepsy to identify key points in the inflammatory cascade that may constitute as therapeutic targets to prevent epileptogenesis.

The implications for developmental epilepsies, ageing and Alzheimer’s disease are under focus. Neurotrophic factors. This group aims to understand the causes and mechanisms of neuronal dysfunction caused by the lack of trophic support to synapse formation/ maturation/ protection.Motor neuron. This group aims to elucidate the fine tune control of motor neuron activity under normal and pathological conditions, as amyotrophic lateral sclerosis (ALS).Following this research line, the group evaluates the synaptic and behavioural (learning, memory, anxiety, depression) consequences of long term manipulation of endogenous modulator (adenosine and cannabinoids) signaling. Modulation of the tripartite synapse. This group aims to elucidate pre- post and glial mechanisms involved in the control of the delicate balance between neuronal inhibition and excitation and its implications for synaptic plasticity.The Unit is constituted by balanced multidisciplinary team organized in five groups according to their specific research topics, as follows: